{"id":13155,"date":"2022-06-07T00:00:00","date_gmt":"2022-06-06T22:00:00","guid":{"rendered":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/?post_type=purple_issue&p=13155"},"modified":"2022-06-08T10:31:35","modified_gmt":"2022-06-08T08:31:35","slug":"quantum-weirdness-could-be-the-driving-force-behind-dna-mutations","status":"publish","type":"post","link":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/2022\/06\/07\/quantum-weirdness-could-be-the-driving-force-behind-dna-mutations\/","title":{"rendered":"Quantum weirdness could be the driving force behind DNA mutations"},"content":{"rendered":"\n

Potentially harmful changes in genetic code may be caused by subatomic particles \u2018tunnelling\u2019 across the DNA helix <\/strong><\/p>\n\n

\"\"<\/figure><\/div>\n\n

Genetic mutations could be caused by quantum effects, researchers from Surrey University have found. Mutations are changes in the DNA of an organism that can result from errors made during cell division, viral infections or exposure to radiation and carcinogens. They are essential to evolution as they can lead to adaptations that allow certain organisms to outcompete others in their environment, but they can also lead to disease.<\/p>\n\n

Mutations can be thought of as \u2018spelling mistakes\u2019 in the genetic code. DNA is made up of four nucleotide bases \u2013 A, C, T and G \u2013 that under normal conditions always bond together in specific ways: A always bonds to T, for example. These bonds form the \u2018rungs\u2019 of the ladder that makes up DNA\u2019s iconic double-helix structure. <\/p>\n\n

However, if the nature of these bonds becomes altered in some way, then the normal pairing rules break down, leading to incorrect bases becoming attached to one another and possibly giving rise to a mutation. <\/p>\n\n

Now, the Surrey team has found that this mismatched bonding may be caused by a mysterious phenomenon known as quantum tunnelling. <\/p>\n\n

Tunnelling occurs when particles move through a barrier that, according to classical physics, they shouldn\u2019t be able to cross. The barrier may be a physically impassable medium, such as an insulator, or a region of high energy that the particle isn\u2019t energetic enough to overcome. <\/p>\n\n

In the case of genetic mutations, researchers found that protons, subatomic particles involved in the bonding of DNA, are continuously tunnelling back and forth across the energy barrier found between the two sides of the helix. <\/p>\n\n

If they do this in the moments before the helix splits along its centre during the first stage of the DNA copying process, some of the protons can get caught on the wrong side. This can lead to an error in copying and, potentially, a mutation. <\/p>\n\n

\u201cBiologists would typically expect tunnelling to play a significant role only at low temperatures and in relatively simple systems,\u201d said the study\u2019s co-author Dr Marco Sacchi. \u201cTherefore, they tended to discount quantum effects in DNA. With our study, we believe we have proved that these assumptions do not hold.\u201d <\/p>\n\n

<\/div>
\n

HOW DNA REPLICATES<\/span><\/h4>\n\n\n\n
\"\"<\/figure><\/div>\n\n\n\n

1. <\/span><\/strong>Portion of DNA about to undergo replication <\/span><\/p>\n\n\n\n

\n\n\n\n
\"\"<\/figure><\/div>\n\n\n\n

2. <\/span><\/strong>The two strands separate. Here, you can see the four \u2018letters\u2019 of the nucleotide bases: <\/span><\/p>\n\n\n\n

A<\/span>,<\/span> C<\/span>, T<\/span> and<\/span> G<\/span> <\/span><\/span><\/span><\/p>\n\n\n\n

\n\n\n\n
\"\"<\/figure><\/div>\n\n\n\n

3.<\/span> <\/strong>The enzyme DNA polymerase reads each strand and attaches complementary bases <\/span><\/p>\n\n\n\n

\n\n\n\n
\"\"<\/figure><\/div>\n\n\n\n

4. <\/span><\/strong>The bases are joined together. <\/span><\/p>\n\n\n\n

A<\/span> goes with<\/span> T,<\/span> and<\/span> C<\/span> goes with<\/span> G <\/span><\/span><\/span><\/span><\/p>\n\n\n\n

\n\n\n\n
\"\"<\/figure><\/div>\n\n\n\n

5.<\/span> <\/strong>Two identical strands of DNA have now been formed <\/span><\/p>\n<\/div><\/section>\n\n

IMAGE: SCIENCE PHOTO LIBRARY<\/p>\n","protected":false},"excerpt":{"rendered":"

Potentially harmful changes in genetic code may be caused by subatomic particles \u2018tunnelling\u2019 across the DNA helix <\/p>\n","protected":false},"author":24,"featured_media":13149,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ub_ctt_via":"","purple_page_number":"19","purple_custom_meta_purple_page_number":"19","purple_seq_number":"1","purple_custom_meta_purple_seq_number":"1","purple_source_article":"article_19-1.xml","purple_custom_meta_purple_source_article":"article_19-1.xml","purple_source_issue":"June-2022","purple_custom_meta_purple_source_issue":"June-2022","purple_external_id":"June-2022-19-1","purple_custom_meta_purple_external_id":"June-2022-19-1","purple_issue_code":"|0000089654||","purple_custom_meta_purple_issue_code":"|0000089654||","purple_android_product":"com.focus.magazine.issue378","purple_custom_meta_purple_android_product":"com.focus.magazine.issue378","purple_ios_product":"com.focus.magazine.issue378","purple_custom_meta_purple_ios_product":"com.focus.magazine.issue378","purple_web_product":"","purple_custom_meta_purple_web_product":"","purple_publication_id":"0f422ad1-c939-476d-9f82-a410052ad4c3","purple_migrated":"","kt_blocks_editor_width":"","apple_news_api_created_at":"2022-06-07T14:37:15Z","apple_news_article-theme":"","apple_news_api_id":"5d59dd43-d596-4f43-9b39-0eb9eb9e31d2","apple_news_api_modified_at":"2022-06-08T08:31:41Z","apple_news_api_revision":"AAAAAAAAAAAAAAAAAAAAAw==","apple_news_api_share_url":"https:\/\/apple.news\/AXVndQ9WWT0ObOQ65654x0g","apple_news_coverimage":0,"apple_news_coverimage_caption":"","apple_news_is_hidden":false,"apple_news_is_paid":true,"apple_news_is_preview":true,"apple_news_is_sponsored":false,"apple_news_maturity_rating":"","apple_news_pullquote":"","apple_news_pullquote_position":"","apple_news_article_theme":"","apple_news_sections":"[]"},"categories":[25],"tags":[15],"apple_news_notices":[],"featured_image_src":"https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/05\/ff990332-9693-47f5-bcd7-d65b367938d0.jpg","author_info":{"display_name":"importmanagerhub@sprylab.com","author_link":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/author\/importmanagerhubsprylab-com\/"},"acf":{"readingTimeMinutes":"3","apple_news_title":""},"uagb_featured_image_src":{"full":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/05\/ff990332-9693-47f5-bcd7-d65b367938d0.jpg",1268,1440,false],"thumbnail":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/05\/ff990332-9693-47f5-bcd7-d65b367938d0-150x150.jpg",150,150,true],"medium":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/05\/ff990332-9693-47f5-bcd7-d65b367938d0-264x300.jpg",264,300,true],"medium_large":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/05\/ff990332-9693-47f5-bcd7-d65b367938d0-768x872.jpg",768,872,true],"large":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/05\/ff990332-9693-47f5-bcd7-d65b367938d0-902x1024.jpg",800,908,true],"1536x1536":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/05\/ff990332-9693-47f5-bcd7-d65b367938d0.jpg",1268,1440,false],"2048x2048":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/05\/ff990332-9693-47f5-bcd7-d65b367938d0.jpg",1268,1440,false]},"uagb_author_info":{"display_name":"importmanagerhub@sprylab.com","author_link":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/author\/importmanagerhubsprylab-com\/"},"uagb_comment_info":0,"uagb_excerpt":"Potentially harmful changes in genetic code may be caused by subatomic particles \u2018tunnelling\u2019 across the DNA helix","_links":{"self":[{"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/posts\/13155"}],"collection":[{"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/comments?post=13155"}],"version-history":[{"count":11,"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/posts\/13155\/revisions"}],"predecessor-version":[{"id":14097,"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/posts\/13155\/revisions\/14097"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/media\/13149"}],"wp:attachment":[{"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/media?parent=13155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/categories?post=13155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/tags?post=13155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}