{"id":12823,"date":"2022-05-06T16:51:29","date_gmt":"2022-05-06T14:51:29","guid":{"rendered":"https:\/\/www.sciencefocus.com\/?p=119087"},"modified":"2022-05-06T17:14:13","modified_gmt":"2022-05-06T15:14:13","slug":"hepatitis-in-children-what-we-know-about-the-surge-in-liver-disease-cases","status":"publish","type":"rss_feed","link":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/rss_feed\/hepatitis-in-children-what-we-know-about-the-surge-in-liver-disease-cases\/","title":{"rendered":"Hepatitis in children: What we know about the surge in liver disease cases"},"content":{"rendered":"

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By Amy Barrett\n \t\t<\/p>

Published: Friday, 06 May 2022 at 12:00 am<\/p>

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The UK Health Security Agency (UKHSA) is looking into 145 cases of hepatitis in children, 10 of whom have needed a liver transplant. At the time of writing, a total of 228 probable hepatitis cases have been reported<\/a> by the World Health Organization (WHO), from 20 countries around the globe.<\/p>\n

Speaking at a WHO media briefing on 1 May 2022, Dr Philippa Easterbrook<\/a> said out of the 20, only 6 countries had seen more than 5 cases. There has been one death attributed to child hepatitis since the sudden rise was reported on 5 April, and the WHO say 18 liver transplants have been performed.<\/p>\n

Scientists do not yet know the cause of the sudden surge in cases of child hepatitis \u2013 an illness that sees the liver inflamed and\/or injured, leading to gastrointestinal symptoms like diarrhoea and vomiting. However there are several hypotheses among the medical community and in the general public. In the UK, testing found that 72 out of 84 children with hepatitis also had an adenovirus infection. This is a common type of virus that can cause illnesses such as colds, fevers, pneumonia, and diarrhoea.<\/p>\n

Due to the sudden onset of hepatitis, research is still ongoing to confirm the cause, or causes, but some of the countries that have seen cases have also reported an increase in adenovirus infections.<\/p>\n

No connection between the surge and one geographic area or common factor (such as particular foods or animals, travel or toxin) has been identified.<\/p>\n

Some have speculated as to whether vaccination for COVID-19 in children could have caused hepatitis, however the WHO report that the majority of children with the illness have not received the vaccine.<\/p>\n

We spoke to liver immunologist Dr Zania Stamataki<\/a> to find out what scientists know about the rise of child hepatitis.<\/p>\n

What is hepatitis?<\/h2>\n

The word hepatitis means inflammation of the liver, and there is no one cause. A patient might have been infected with a virus that caused liver inflammation, or they might have consumed a toxin that inflamed their liver. Some people might get hepatitis because they have an autoimmune disease that causes their immune system to attack their own body, leading to inflammation.<\/p>\n

\u201cIn fact, a lot of the cases of hepatitis that we are getting nowadays are because of our high fat diet; that injures the liver as well,\u201d said Stamataki.<\/p>\n

But the language around this recent increase in child hepatitis cases can cause confusion as to its source, said Stamataki.<\/p>\n

\u201cWhen you read things like \u2018hepatitis outbreak\u2019, it might imply that its definitely caused by an infectious agent. The way we\u2019re talking about it, a lot of people can mistake hepatitis for a viral illness. But actually, liver inflammation can occur from multiple different aetiologies.<\/p>\n

\u201cSo. because we don\u2019t know [the cause] yet, it\u2019s better if we use language that describes this as a disease of unknown origin.\u201d<\/p>\n

Is hepatitis serious in children?<\/h2>\n

In cases of acute, short-term hepatitis, the inflammation usually resolves itself quickly.<\/p>\n

\u201cThe liver is a tremendous organ. It\u2019s our biggest internal organ and it\u2019s the only one that has the ability to grow back,\u201d said Stamataki. \u201cYou can cut a healthy liver and it will grow back and regenerate to the size that it needs to support your body.\u201d<\/p>\n

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There are several things that can cause hepatitis, including viruses such as the one pictured here, which causes a type of liver inflammation called Hepatitis C \u00a9 Getty Images<\/span><\/figcaption><\/div>\n

It\u2019s not uncommon for someone to have mild hepatitis without ever recognising any symptoms. But, even if the damage to the liver is broader and causes more symptoms, the hepatitis clears up quickly, particularly in children. If the cause of the hepatitis is a virus, such as the common cold-causing adenovirus, the liver will usually recover as soon as the virus has gone away.<\/p>\n

In the UK, babies are vaccinated against one certain type of viral-induced hepatitis as part of their regular vaccination programme.<\/p>\n

What are the symptoms of child hepatitis?<\/h2>\n

Symptoms of child hepatitis to look out for are tummy aches and pains, diarrhoea and vomiting, and jaundice \u2013 where the skin and the whites of the eyes appear yellow.<\/p>\n

\u201cThese are clues that something is happening in the liver,\u201d said Stamataki. \u201cIf this occurs, you go to the doctors\u2019 and they take a blood test, looking for liver enzymes. If they\u2019re found to be elevated, that means that there\u2019s been some damage into your liver.\u201d<\/p>\n

According to the NHS, symptoms of acute hepatitis<\/a> can also include things like muscle and joint pain, a high temperature, loss of appetite, and dark urine.\u00a0<\/strong><\/p>\n

Can a child recover from hepatitis?<\/h2>\n

Most instances of hepatitis resolve themselves quickly and do not need treatment.<\/p>\n

However, the newly identified cases are linked to more severe hepatitis, requiring hospitalisation and treatment. So far, just under 8 per cent of children with this severe, sudden onset hepatitis have needed a liver transplant.\u00a0<\/strong><\/p>\n

\"""\"<\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/picture><\/div>
It has been suggested that a lack of socialising due to COVID-19 lockdowns has left children vulnerable to infections, however Dr Zania Stamataki believes that if this were the cause, there would be a much larger number of cases \u00a9 Getty Images<\/span><\/figcaption><\/div>\n

How many children have hepatitis?<\/h2>\n

As of 1 May, 228 children worldwide have been reported to have severe hepatitis. At this point in the year, doctors would not expect to see this many cases, said Stamataki.<\/p>\n

However, occurrences are still rare. Of the roughly 8.7 million children under the age 10 in the UK<\/a>, there are 145 cases currently under investigation by UKHSA. Of these, there are 108 children living in England, 17 in Scotland, 11 in Wales and 9 in Northern Ireland.<\/p>\n

\u201cThis is a very, very rare disease. So, as a mum, I\u2019m not hugely concerned,\u201d said Stamataki. \u201cBut as a viral immunologist, it is raising an eyebrow, because the incidence of these cases are higher compared to pre-pandemic levels.\u201d<\/p>\n

It could be that more children have had hepatitis by the same cause as with the severe cases, but that their symptoms were mild and their recovery quick, so they went unnoticed, said Stamataki.<\/p>\n

What is causing the new cases of child hepatitis?<\/h2>\n

There are several hypotheses for what is causing the sudden rise in child hepatitis. It could be due to an infection with a virus, that then damaged the liver. This infection could have occurred quite a while ago, causing damage to the liver that just hasn\u2019t resolved, Stamataki said.<\/p>\n

One possible cause being investigated by researchers is a particular type of virus called adenovirus 41, which can cause cold-like symptoms but also diarrhoea and fever.<\/p>\n

\u201cAdenovirus 41 has been identified in some of these children\u2026 and it could be that it\u2019s related [to the hepatitis onset], but it could be that it\u2019s completely unrelated to these cases, because adenoviruses currently circulating as with other seasonal viruses [in the general population].\u201d<\/p>\n

\u201cNow, adenovirus 41 previously has not really been linked to liver injury\u2026 So it is unusual that adenovirus 41 could be causing this,\u201d said Stamataki.<\/p>\n

Studies are ongoing to investigate the possible cause of the rise in cases, with some looking at the immune response, genetics and rates of adenovirus within hospitals.\u00a0<\/strong><\/p>\n

Is the increase in hepatitis cases due to COVID-19 lockdowns?<\/h2>\n

Some have suggested that the sudden rise in cases could be due to COVID-19 lockdowns<\/a>, as children had not been exposed to as many viruses and infections that have enabled them to build up their immune systems.<\/p>\n

\u201cIt\u2019s an interesting hypothesis,\u201d said Stamataki. \u201cChildren need viral infection over the years to build up their immunity to incoming viruses. But this still doesn\u2019t explain why only a handful of those children had severe disease, and how this has affected the liver.\u201d<\/p>\n

Again, of the 8.7 million children affected by lockdown, only 145 hepatitis cases have been reported so far \u2013 an occurrence of around 0.0016 per cent.<\/p>\n

Could the COVID-19 virus have caused hepatitis?<\/h2>\n

Health officials have said that around 16 per cent of UK cases were positive for coronavirus when they were admitted to hospital. However, as levels of COVID-19 were high in the general population at that time, it would not be unexpected for the children to test positive.\u00a0<\/strong><\/p>\n

The UKHSA are looking into whether infection with COVID-19 could be linked<\/a> to severe hepatitis.<\/p>\n

\u201cBefore the pandemic, cases of sudden onset hepatitis were never linked to coronaviruses,\u201d said Stamataki. \u201cBut SARS-CoV-2 is a new virus, so we\u2019re only starting to understand how it works. It\u2019s possible that the virus affects cells and organs in different people differently, and we know that it can take a little while for the body to recover [sometimes resulting in cases of long COVID<\/a>].<\/p>\n

\u201cThe question is, with so many thousands of children are getting COVID at the moment, why are these children getting liver failure? I suspect that it is more than one thing causing this liver injury that\u2019s difficult to recover [from].\u201d<\/p>\n

How can I protect my child from hepatitis?<\/h2>\n

The NHS recommends parents engage in good hygiene practices, such as supervising young children as they wash their hands, to prevent infections that can cause hepatitis.<\/p>\n

Parents are encouraged to see their GP if their child has hepatitis symptoms, including jaundice. Any child experiencing vomiting and diarrhoea should stay at home and only return to school or nursery once 48 hours have passed without these symptoms.<\/p>\n

Read more science news:<\/strong><\/p>\n