{"id":6361,"date":"2022-03-04T17:08:47","date_gmt":"2022-03-04T16:08:47","guid":{"rendered":"https:\/\/www.sciencefocus.com\/?p=112980"},"modified":"2022-03-04T17:24:12","modified_gmt":"2022-03-04T16:24:12","slug":"eat-lots-of-seaweed-the-key-to-curing-metabolic-disorders-could-be-in-your-gut","status":"publish","type":"rss_feed","link":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/rss_feed\/eat-lots-of-seaweed-the-key-to-curing-metabolic-disorders-could-be-in-your-gut\/","title":{"rendered":"Eat lots of seaweed? The key to curing metabolic disorders could be in your gut"},"content":{"rendered":"<p class=\"rssexcerpt\"><\/p><p class=\"rssauthor\">By Amy Barrett\n                \t\t<\/p><p class=\"rssbyline\">Published: Friday, 04 March 2022 at 12:00 am<\/p><hr class=\"no-tts wp-block-separator\"\/><?xml version=\"1.0\" encoding=\"UTF-8\" standalone=\"yes\"?>\n<!DOCTYPE html PUBLIC \"-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\" \"http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\">\n<html><body><p>A special type of seaweed-eating bacteria found in the human gut could be used to treat serious illnesses like kidney disease.<\/p>\n<p>These bacteria \u2013 called <em>Bacteroidetes<\/em> \u2013 help people to digest the fibres found in seaweed, which are different to those found in things like fruits, vegetables, grains and nuts. However, not everyone has these bacteria in their <a href=\"&quot;https:\/\/www.sciencefocus.com\/the-human-body\/how-to-boost-your-microbiome\/&quot;\">gut microbiome<\/a> \u2013 without them, you\u2019re not able to break down seaweed found in foods like sushi or Welsh laverbread. It\u2019s unlikely that you\u2019ll feel any negative side effects to their absence, though.<\/p>\n<p>By understanding how these specialised bacteria have evolved, researchers hope to develop gut-friendly bacteria that can be genetically engineered to perform as treatments.<\/p>\n<p><strong>Read more about the gut microbiome:<\/strong><\/p>\n<ul><li><a href=\"&quot;https:\/\/www.sciencefocus.com\/news\/pandas-shifting-gut-bacteria-help-them-stay-chubby-on-an-all-bamboo-diet\/&quot;\">Panda\u2019s shifting gut bacteria help them stay chubby on an all-bamboo diet<\/a><\/li>\n<li><a href=\"&quot;https:\/\/www.sciencefocus.com\/the-human-body\/dr-michael-mosley-mediterranean-diet-fart\/&quot;\">Dr Michael Mosley: The Mediterranean diet is great for your gut (even if it makes you fart)<\/a><\/li>\n<\/ul><p>To learn more about these bacteria, scientists at the University of Michigan Medical School tested 354 faecal samples, taken from their undergraduate students. These were then introduced to four seaweed fibres: porphyran, laminarin, alginate and carrageenan.<\/p>\n<p>Laminarin is similar to another group of compounds, beta-glucans, which are more common in cereals like oat, barley, wheat and rye, and in fungi and yeasts. This, the researchers believe, could be why they <a href=\"\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1931312822000877?via%3Dihub&quot;\" target=\"&quot;_blank&quot;\" rel=\"&quot;noopener&quot; noopener noreferrer\">found the bacteria needed to break down laminarin in many of the samples<\/a>. The bacteria needed to break down the three other fibre types were rare among their student population, even though carrageenan is found in many processed foods, where it acts like gelatine.<\/p>\n<p>The team then looked at the genetic make-up of the bacteria. Surprisingly, they noticed that it wasn\u2019t just the <em>Bacteroidetes <\/em>species that was breaking down the seaweed. Another common gut bacteria, <em>Firmicutes<\/em>, had somehow \u2018picked up\u2019 the genes needed to break down the fibres.<\/p>\n<p>\u201cBacteria in general, and bacteria in the human gut in particular, are very adept at exchanging genes,\u201d said <a href=\"\/\/medicine.umich.edu\/dept\/microbiology-immunology\/eric-martens-phd&quot;\" target=\"&quot;_blank&quot;\" rel=\"&quot;noopener&quot; noopener noreferrer\">Dr Eric Martens<\/a>, one of the lead authors of the new study. \u201cThey can exchange abilities like [the breakdown of seaweed], but others also. They can exchange antibiotic resistance traits, which is part of the reason why or antibiotic resistance is such a problem.\u201d<\/p>\n<p>Martens says previous studies, such as one in 2010 by a co-author <a href=\"\/\/www.mpi-bremen.de\/print\/en\/https-www.mpi-bremen.de-en-Page2575.html.html&quot;\" target=\"&quot;_blank&quot;\" rel=\"&quot;noopener&quot; noopener noreferrer\">Dr Jan Hendrik Hehemann<\/a>, show that the human gut bacteria share a common ancestor with <a href=\"&quot;https:\/\/www.nature.com\/articles\/nature08937&quot;\">a marine bacteria that lives in the ocean and feeds on seaweed there<\/a>. How the genes from the marine bacteria ended up in bacteria in the human microbiome \u201cremains a mystery\u201d.<\/p>\n<p>\u201cWhen we sequenced the genomes of these organisms, we a lot of things moving between bacteria. But we don\u2019t know how frequently these exchange events happen, and we don\u2019t know how these genes get into those [bacteria in the first place].\u201d<\/p>\n<div class=\"&quot;image-handler__container\" image-handler__container--full=\"\" style=\"&quot;padding-bottom:\" calc=\"\"> <picture><source media=\"&quot;(max-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?webp=true&amp;quality=90&amp;resize=300%2C200,\" https:=\"\" type=\"&quot;image\/webp&quot;\"><source media=\"&quot;(max-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?quality=90&amp;resize=300%2C200,\" https:=\"\" type=\"&quot;image\/jpeg&quot;\"><source media=\"&quot;(max-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?webp=true&amp;quality=90&amp;resize=355%2C237,\" https:=\"\" type=\"&quot;image\/webp&quot;\"><source media=\"&quot;(max-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?quality=90&amp;resize=355%2C237,\" https:=\"\" type=\"&quot;image\/jpeg&quot;\"><source media=\"&quot;(max-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?webp=true&amp;quality=90&amp;resize=405%2C270,\" https:=\"\" type=\"&quot;image\/webp&quot;\"><source media=\"&quot;(max-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?quality=90&amp;resize=405%2C270,\" https:=\"\" type=\"&quot;image\/jpeg&quot;\"><source media=\"&quot;(max-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?webp=true&amp;quality=90&amp;resize=554%2C370,\" https:=\"\" type=\"&quot;image\/webp&quot;\"><source media=\"&quot;(max-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?quality=90&amp;resize=554%2C370,\" https:=\"\" type=\"&quot;image\/jpeg&quot;\"><source media=\"&quot;(min-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?webp=true&amp;quality=90&amp;resize=620%2C414&quot;\" type=\"&quot;image\/webp&quot;\"><source media=\"&quot;(min-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?quality=90&amp;resize=620%2C414&quot;\" type=\"&quot;image\/jpeg&quot;\"><source media=\"&quot;(min-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?webp=true&amp;quality=90&amp;resize=408%2C272,\" https:=\"\" type=\"&quot;image\/webp&quot;\"><source media=\"&quot;(min-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?quality=90&amp;resize=408%2C272,\" https:=\"\" type=\"&quot;image\/jpeg&quot;\"><source media=\"&quot;(min-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?webp=true&amp;quality=90&amp;resize=556%2C371,\" https:=\"\" type=\"&quot;image\/webp&quot;\"><source media=\"&quot;(min-width:\" data-srcset=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?quality=90&amp;resize=556%2C371,\" https:=\"\" type=\"&quot;image\/jpeg&quot;\"><img class=\"&quot;wp-image-113023\" align=\"\" size-full=\"\" image-handler__image=\"\" image-handler__image--full=\"\" no-wrap=\"\" js-lazyload=\"\" data-src=\"&quot;https:\/\/images.immediate.co.uk\/production\/volatile\/sites\/4\/2022\/03\/GettyImages-623535742-3946c50.jpg?quality=90&amp;resize=620%2C414&quot;\" width=\"&quot;620&quot;\" height=\"&quot;413&quot;\" alt=\"&quot;A\" bowl=\"\" of=\"\" ramen=\"\" topped=\"\" with=\"\" roasted=\"\" seaweed=\"\" title=\"&quot;Seaweed\" is=\"\" found=\"\" in=\"\" many=\"\" foods=\"\" including=\"\" sushi=\"\" crispy=\"\" nori=\"\" snacks=\"\" and=\"\" laverbread=\"\" getty=\"\" images=\"\"\/><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/source><\/picture><\/div><div class=\"&quot;caption-hold&quot;\"><figcaption class=\"&quot;wp-caption-text&quot;\"><span class=\"&quot;caption-copy&quot;\"><i class=\"&quot;icon-arrow\" icon-camera-circle=\"\"\/> Seaweed is found in many foods, including sushi, ramen (pictured), crispy nori snacks and laverbread \u00a9 Getty Images<\/span><\/figcaption><span class=\"&quot;im-image-caption&quot;\"\/><\/div>\n<p>Now, scientists are looking to understand exactly how these gene exchanges happen. The knowledge could offer new treatments, as studies show <a href=\"&quot;https:\/\/www.nature.com\/articles\/s41586-018-0092-4&quot;\">bacteria can be engineered to carry particular genes into a person\u2019s gut<\/a> and exchange them with the other members of the microbiome.<\/p>\n<p>\u201cThere are really interesting biotechnological applications here,\u201d said Martens. One company utilising the technology is called <a href=\"\/\/novomebio.com\/&quot;\" target=\"&quot;_blank&quot;\" rel=\"&quot;noopener&quot; noopener noreferrer\">Novome<\/a>, which Martens is currently collaborating with. Novome are using a variant of the seaweed-digesting bacteria and genetically engineering it to perform other functions.<\/p>\n<p>Current clinical trials are investigating whether the bacteria could treat a condition called hyperoxaluria, where people can\u2019t properly process oxalic acid, a nutrient found in leafy greens. People who have high levels of oxalic acid will get kidney stones more frequently and can develop chronic kidney disease.<\/p>\n<p>But Novome have genetically-engineered a seaweed-eating bacteria to also hold the gene for processing oxalic acid.<\/p>\n<p>While these engineered bacteria could be given as a probiotic, Martens explains this would rely on the bacteria being able to grow within the gut, competing with all the other bacterial colonies that have been established in your microbiome over a long time.<\/p>\n<p>\u201cMost over-the-counter probiotics nowadays don\u2019t colonise your gastrointestinal (GI) tract very well, because even if you took a really big capsule for a full of probiotics, you\u2019re at most getting 10- to 100-billion bacteria. These are vastly outnumbered by the bacteria that are already in [your gut] and there who are better adapted to being there.\u201d<\/p>\n<p>Instead, Novome are supplementing their engineered bacteria with seaweed, to give it the best chance of colonising. \u201cThe seaweed can help the bacteria implant into their GI tract to process the [excess] oxalic acid,\u201d said Martens.<\/p>\n<section class=\"&quot;highlight\"><div class=\"&quot;highlight__content\" editor-content=\"\"> <h4>About our expert<\/h4>\n<p><strong>Dr Eric Martens<\/strong> runs the Martens Lab at the University of Michigan Medical School, where he and his team further our understanding of the human gastrointestinal tract.<\/p>\n<p> <\/p><\/div> <\/section><\/body><\/html>\n<hr class=\"no-tts wp-block-separator\"\/>","protected":false},"excerpt":{"rendered":"<p>By Amy Barrett Published: Friday, 04 March 2022 at 12:00 am A special type of seaweed-eating bacteria found in the human gut could be used to treat serious illnesses like kidney disease. These bacteria \u2013 called Bacteroidetes \u2013 help people to digest the fibres found in seaweed, which are different to those found in things [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":6362,"template":"","categories":[1],"acf":{"readingTimeMinutes":"4"},"uagb_featured_image_src":{"full":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/03\/eat-lots-of-seaweed-the-key-to-curing-metabolic-disorders-could-be-in-your-gut.jpg",1200,798,false],"thumbnail":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/03\/eat-lots-of-seaweed-the-key-to-curing-metabolic-disorders-could-be-in-your-gut-150x150.jpg",150,150,true],"medium":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/03\/eat-lots-of-seaweed-the-key-to-curing-metabolic-disorders-could-be-in-your-gut-300x200.jpg",300,200,true],"medium_large":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/03\/eat-lots-of-seaweed-the-key-to-curing-metabolic-disorders-could-be-in-your-gut-768x511.jpg",768,511,true],"large":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/03\/eat-lots-of-seaweed-the-key-to-curing-metabolic-disorders-could-be-in-your-gut-1024x681.jpg",800,532,true],"1536x1536":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/03\/eat-lots-of-seaweed-the-key-to-curing-metabolic-disorders-could-be-in-your-gut.jpg",1200,798,false],"2048x2048":["https:\/\/c01.purpledshub.com\/uploads\/sites\/42\/2022\/03\/eat-lots-of-seaweed-the-key-to-curing-metabolic-disorders-could-be-in-your-gut.jpg",1200,798,false]},"uagb_author_info":{"display_name":"importmanagerhub@sprylab.com","author_link":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/author\/importmanagerhubsprylab-com\/"},"uagb_comment_info":0,"uagb_excerpt":"By Amy Barrett Published: Friday, 04 March 2022 at 12:00 am A special type of seaweed-eating bacteria found in the human gut could be used to treat serious illnesses like kidney disease. These bacteria \u2013 called Bacteroidetes \u2013 help people to digest the fibres found in seaweed, which are different to those found in things&hellip;","_links":{"self":[{"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/rss_feed\/6361"}],"collection":[{"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/rss_feed"}],"about":[{"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/types\/rss_feed"}],"author":[{"embeddable":true,"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/users\/24"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/media\/6362"}],"wp:attachment":[{"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/media?parent=6361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/c01.purpledshub.com\/bbcsciencefocus\/wp-json\/wp\/v2\/categories?post=6361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}